Drug interactions
Azelastine + Lofepramine
Severity: Moderate
Azelastine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic effects. Adding azelastine can increase drowsiness and anticholinergic burden.
What this interaction means in plain words
Azelastine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative effects from H1 blockade by both drugs.
What to do
Monitor for sedation and anticholinergic effects, particularly in older patients. Prefer a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Lofepramine?
MediHelp rates the interaction as moderate. Azelastine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic effects. Adding azelastine can increase drowsiness and anticholinergic burden.
How serious is the interaction between Azelastine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, particularly in older patients. Prefer a non-sedating antihistamine if needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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