Drug interactions
Azelastine + Loprazolam
Severity: Moderate
Azelastine and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loprazolam is a benzodiazepine hypnotic and azelastine is sedating. Together they may intensify drowsiness and impair next-day alertness.
What this interaction means in plain words
Azelastine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and H1 blockade.
What to do
Monitor for oversedation and counsel on driving. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Loprazolam?
MediHelp rates the interaction as moderate. Azelastine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loprazolam is a benzodiazepine hypnotic and azelastine is sedating. Together they may intensify drowsiness and impair next-day alertness.
How serious is the interaction between Azelastine and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel on driving. Consider a non-sedating antihistamine.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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