Drug interactions
Azelastine + Passion flower
Severity: Minor
Azelastine and Passion flower: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passion flower has sedative and anxiolytic properties that may add to the drowsiness caused by azelastine. The clinical evidence is limited and largely theoretical.
What this interaction means in plain words
Azelastine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Presumed additive CNS depression, likely via GABAergic activity of the herb.
What to do
Advise the patient to watch for excess drowsiness and avoid driving if affected. Stop the herbal product if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Passion flower?
MediHelp rates the interaction as minor. Azelastine and Passion flower have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passion flower has sedative and anxiolytic properties that may add to the drowsiness caused by azelastine. The clinical evidence is limited and largely theoretical.
How serious is the interaction between Azelastine and Passion flower?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to watch for excess drowsiness and avoid driving if affected. Stop the herbal product if sedation becomes troublesome.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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