Drug interactions
Azelastine + Phenobarbital
Severity: Moderate
Azelastine and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital causes sedation and azelastine can add to drowsiness and reduced psychomotor performance. Impairment may be marked at the start of treatment or after dose increases.
What this interaction means in plain words
Azelastine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the barbiturate and the sedating antihistamine.
What to do
Counsel on drowsiness and avoid driving until the response is known. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Phenobarbital?
MediHelp rates the interaction as moderate. Azelastine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital causes sedation and azelastine can add to drowsiness and reduced psychomotor performance. Impairment may be marked at the start of treatment or after dose increases.
How serious is the interaction between Azelastine and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until the response is known. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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