Drug interactions
Azelastine + Pimozide
Severity: Moderate
Azelastine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may cause drowsiness, so combined use can increase sedation and impair alertness. Pimozide also carries a risk of QT prolongation, which makes it important to review the whole medication list for other QT-active drugs.
What this interaction means in plain words
Azelastine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and dopamine antagonism with antihistaminic effects of pimozide.
What to do
Monitor for oversedation and counsel on driving and alcohol. Ensure ECG and electrolyte monitoring as already indicated for pimozide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Azelastine with Pimozide?
MediHelp rates the interaction as moderate. Azelastine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may cause drowsiness, so combined use can increase sedation and impair alertness. Pimozide also carries a risk of QT prolongation, which makes it important to review the whole medication list for other QT-active drugs.
How serious is the interaction between Azelastine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel on driving and alcohol. Ensure ECG and electrolyte monitoring as already indicated for pimozide.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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