Drug interactions
Azelastine + Protriptyline
Severity: Moderate
Azelastine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with anticholinergic effects, although it is less sedating than other tricyclics. Together with azelastine, drowsiness and anticholinergic effects may be additive.
What this interaction means in plain words
Azelastine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for sedation and anticholinergic effects such as dry mouth and urinary retention. Avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Protriptyline?
MediHelp rates the interaction as moderate. Azelastine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant with anticholinergic effects, although it is less sedating than other tricyclics. Together with azelastine, drowsiness and anticholinergic effects may be additive.
How serious is the interaction between Azelastine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects such as dry mouth and urinary retention. Avoid driving if drowsy.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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