Drug interactions
Azelastine + Triazolam
Severity: Moderate
Azelastine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a short-acting benzodiazepine hypnotic and azelastine can add to sedation and psychomotor impairment. Risk is greater in older adults.
What this interaction means in plain words
Azelastine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antihistaminic sedation.
What to do
Counsel on sedation and avoid alcohol and driving. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Triazolam?
MediHelp rates the interaction as moderate. Azelastine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a short-acting benzodiazepine hypnotic and azelastine can add to sedation and psychomotor impairment. Risk is greater in older adults.
How serious is the interaction between Azelastine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid alcohol and driving. Prefer a non-sedating antihistamine.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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