Drug interactions
Azelastine + Yohimbine
Severity: Minor
Azelastine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is sedating while yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, so the two may partly oppose each other. The net clinical effect is unpredictable and not well documented.
What this interaction means in plain words
Azelastine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects (antihistaminic sedation versus alpha-2 adrenergic antagonism); the interaction is not well characterized.
What to do
No dose change is required; monitor for reduced antihistamine sedation or for unexpected agitation or tachycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine and Yohimbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Yohimbine?
MediHelp rates the interaction as minor. Azelastine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine is sedating while yohimbine is an alpha-2 antagonist with stimulant and anxiogenic effects, so the two may partly oppose each other. The net clinical effect is unpredictable and not well documented.
How serious is the interaction between Azelastine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for reduced antihistamine sedation or for unexpected agitation or tachycardia.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
