Drug interactions
Bacitracin-neomycin-polymyxin + Cephaloridine
Severity: Moderate
Bacitracin-neomycin-polymyxin and Cephaloridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephaloridine is a nephrotoxic cephalosporin no longer in common use. Combining it with neomycin or polymyxin B, if systemically absorbed, may increase the risk of kidney injury.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Cephaloridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from proximal tubular injury.
What to do
Avoid combining where feasible and prefer a less nephrotoxic cephalosporin. If used together, monitor renal function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Cephaloridine?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Cephaloridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephaloridine is a nephrotoxic cephalosporin no longer in common use. Combining it with neomycin or polymyxin B, if systemically absorbed, may increase the risk of kidney injury.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Cephaloridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where feasible and prefer a less nephrotoxic cephalosporin. If used together, monitor renal function regularly.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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