Drug interactions
Bacitracin-neomycin-polymyxin + Contrast media
Severity: Moderate
Bacitracin-neomycin-polymyxin and Contrast media: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and polymyxin B is nephrotoxic and neurotoxic when systemically absorbed. With topical bacitracin-neomycin-polymyxin on intact skin absorption is minimal, but use on large wounds or irrigation can add risk.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Contrast media can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from contrast-induced tubular injury and polymyxin/neomycin tubular toxicity.
What to do
Avoid using the combination product on large open wounds or by irrigation around contrast studies. If systemic exposure is likely, ensure hydration and monitor serum creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Contrast media?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Contrast media can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause acute kidney injury, and polymyxin B is nephrotoxic and neurotoxic when systemically absorbed. With topical bacitracin-neomycin-polymyxin on intact skin absorption is minimal, but use on large wounds or irrigation can add risk.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Contrast media?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the combination product on large open wounds or by irrigation around contrast studies. If systemic exposure is likely, ensure hydration and monitor serum creatinine.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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