Drug interactions
Bacitracin-neomycin-polymyxin + Cyclosporine
Severity: Moderate
Bacitracin-neomycin-polymyxin and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine is nephrotoxic, and the aminoglycoside and polymyxin components can add to kidney injury if absorbed systemically. This matters mainly with irrigation, large raw areas, or damaged skin, as intact-skin use gives little exposure.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from calcineurin-inhibitor renal vasoconstriction and aminoglycoside/polymyxin tubular toxicity.
What to do
Restrict the product to small areas of intact or minimally broken skin. Monitor serum creatinine and cyclosporine levels if there is a significant absorbing surface.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Cyclosporine?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine is nephrotoxic, and the aminoglycoside and polymyxin components can add to kidney injury if absorbed systemically. This matters mainly with irrigation, large raw areas, or damaged skin, as intact-skin use gives little exposure.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Restrict the product to small areas of intact or minimally broken skin. Monitor serum creatinine and cyclosporine levels if there is a significant absorbing surface.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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