Drug interactions
Bacitracin-neomycin-polymyxin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Bacitracin-neomycin-polymyxin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil and cobicistat can affect renal function, and cobicistat raises serum creatinine by inhibiting tubular secretion. Neomycin and polymyxin B are nephrotoxic if absorbed, so combined use may increase the risk of kidney injury.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from proximal tubular effects of tenofovir and absorbed aminoglycoside or polymyxin.
What to do
Topical use on small areas needs no change. With systemic or extensive use, monitor serum creatinine, phosphate and urine protein, and avoid the combination if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil and cobicistat can affect renal function, and cobicistat raises serum creatinine by inhibiting tubular secretion. Neomycin and polymyxin B are nephrotoxic if absorbed, so combined use may increase the risk of kidney injury.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Topical use on small areas needs no change. With systemic or extensive use, monitor serum creatinine, phosphate and urine protein, and avoid the combination if renal function declines.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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