Drug interactions
Bacitracin-neomycin-polymyxin + Ioversol
Severity: Moderate
Bacitracin-neomycin-polymyxin and Ioversol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ioversol is an iodinated contrast agent that can injure the kidney, and absorbed polymyxin B and neomycin may add nephrotoxicity. The concern is limited for topical use on small areas of intact skin.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from contrast-induced tubular injury and polymyxin/neomycin tubular toxicity.
What to do
Avoid applying the combination to large wounds or using it for irrigation around contrast exposure. Monitor serum creatinine if systemic absorption is likely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Ioversol?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Ioversol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ioversol is an iodinated contrast agent that can injure the kidney, and absorbed polymyxin B and neomycin may add nephrotoxicity. The concern is limited for topical use on small areas of intact skin.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Ioversol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid applying the combination to large wounds or using it for irrigation around contrast exposure. Monitor serum creatinine if systemic absorption is likely.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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