Drug interactions
Bacitracin-neomycin-polymyxin + Methoxyflurane
Severity: Moderate
Bacitracin-neomycin-polymyxin and Methoxyflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride that can cause kidney toxicity, and absorbed neomycin or polymyxin B may add to this. Analgesic doses of inhaled methoxyflurane are low, and topical antibiotics on intact skin rarely reach significant systemic levels.
What this interaction means in plain words
Bacitracin-neomycin-polymyxin and Methoxyflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from fluoride-induced renal tubular injury and aminoglycoside/polymyxin toxicity.
What to do
Avoid combining where significant absorption of the antibiotic is likely, such as large wounds or irrigation. Monitor renal function if both are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Major
- Atracurium + Bacitracin-neomycin-polymyxin Major
- Bacitracin-neomycin-polymyxin + Capreomycin Major
- Bacitracin-neomycin-polymyxin + Cidofovir Major
- Bacitracin-neomycin-polymyxin + Cisatracurium Major
- Bacitracin-neomycin-polymyxin + Pancuronium Major
Frequently asked questions
Can I take Bacitracin-neomycin-polymyxin with Methoxyflurane?
MediHelp rates the interaction as moderate. Bacitracin-neomycin-polymyxin and Methoxyflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxyflurane releases fluoride that can cause kidney toxicity, and absorbed neomycin or polymyxin B may add to this. Analgesic doses of inhaled methoxyflurane are low, and topical antibiotics on intact skin rarely reach significant systemic levels.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Methoxyflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where significant absorption of the antibiotic is likely, such as large wounds or irrigation. Monitor renal function if both are needed.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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