Drug interactions
Baclofen + Brexanolone
Severity: Major
Baclofen and Brexanolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
What this interaction means in plain words
Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression, with brexanolone acting as a positive GABA-A modulator and baclofen as a GABA-B agonist.
What to do
Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Brexanolone?
MediHelp rates the interaction as major. Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
How serious is the interaction between Baclofen and Brexanolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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