Drug interactions
Baricitinib + Glimepiride-pioglitazone
Severity: Minor
Baricitinib and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is an OAT3 substrate and OAT3 inhibitors reduce its clearance. Pioglitazone is not a recognized clinically meaningful OAT3 inhibitor, so the concern is not well supported.
What this interaction means in plain words
Baricitinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Theoretical OAT3 inhibition reducing renal elimination of baricitinib; not established for pioglitazone.
What to do
No dose adjustment is generally needed; monitor for baricitinib adverse effects such as infection or cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Baricitinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Baricitinib is an OAT3 substrate and OAT3 inhibitors reduce its clearance. Pioglitazone is not a recognized clinically meaningful OAT3 inhibitor, so the concern is not well supported.
How serious is the interaction between Baricitinib and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for baricitinib adverse effects such as infection or cytopenias as usual.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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