Drug interactions
Baricitinib + Influenza virus vaccine quadrivalent intranasal
Severity: Major
Baricitinib and Influenza virus vaccine quadrivalent intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus. In a patient taking baricitinib, the vaccine strain could replicate excessively and cause vaccine-related infection, and the immune response may be weaker.
What this interaction means in plain words
Baricitinib and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
JAK inhibition impairs immune control of live attenuated virus replication and vaccine response.
What to do
Do not give live intranasal vaccine during baricitinib therapy; use inactivated injectable influenza vaccine instead. Complete live vaccinations before starting baricitinib according to immunization guidelines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as major. Baricitinib and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The intranasal influenza vaccine contains live attenuated virus. In a patient taking baricitinib, the vaccine strain could replicate excessively and cause vaccine-related infection, and the immune response may be weaker.
How serious is the interaction between Baricitinib and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live intranasal vaccine during baricitinib therapy; use inactivated injectable influenza vaccine instead. Complete live vaccinations before starting baricitinib according to immunization guidelines.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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