Drug interactions
Baricitinib + Ketorolac
Severity: Moderate
Baricitinib and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac may raise baricitinib exposure by slowing its renal elimination. Higher baricitinib levels could increase the risk of dose-related adverse effects such as infection and cytopenias. The clinical significance of OAT3 inhibition by ketorolac specifically is less well characterized than for strong inhibitors such as probenecid.
What this interaction means in plain words
Baricitinib and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.
Why it happens
Inhibition of organic anion transporter 3 mediated renal tubular secretion of baricitinib.
What to do
Monitor for infections and blood count abnormalities, and consider a non-NSAID analgesic. Limit ketorolac to short courses, and note that its renal toxicity may also further raise baricitinib exposure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Ketorolac?
MediHelp rates the interaction as moderate. Baricitinib and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac may raise baricitinib exposure by slowing its renal elimination. Higher baricitinib levels could increase the risk of dose-related adverse effects such as infection and cytopenias. The clinical significance of OAT3 inhibition by ketorolac specifically is less well characterized than for strong inhibitors such as probenecid.
How serious is the interaction between Baricitinib and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections and blood count abnormalities, and consider a non-NSAID analgesic. Limit ketorolac to short courses, and note that its renal toxicity may also further raise baricitinib exposure.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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