Drug interactions
Baricitinib + Measles mumps rubella and varicella vaccine live
Severity: Major
Baricitinib and Measles mumps rubella and varicella vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combined live vaccine contains attenuated viruses that could spread uncontrolled in a patient immunosuppressed by baricitinib, causing disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
What this interaction means in plain words
Baricitinib and Measles mumps rubella and varicella vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
JAK inhibition impairs immune control of live attenuated virus replication.
What to do
Avoid live vaccines during baricitinib therapy. Complete required immunizations before starting baricitinib according to current guidelines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as major. Baricitinib and Measles mumps rubella and varicella vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This combined live vaccine contains attenuated viruses that could spread uncontrolled in a patient immunosuppressed by baricitinib, causing disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
How serious is the interaction between Baricitinib and Measles mumps rubella and varicella vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during baricitinib therapy. Complete required immunizations before starting baricitinib according to current guidelines.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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