Drug interactions
Baricitinib + Mechlorethamine
Severity: Major
Baricitinib and Mechlorethamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib is immunosuppressive, and systemic mechlorethamine is myelosuppressive, so combined use may raise the risk of serious infection. Topical mechlorethamine has minimal systemic exposure, but the formulation is not specified here.
What this interaction means in plain words
Baricitinib and Mechlorethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Mechlorethamine belongs to Oncology.
Why it happens
Additive immunosuppression and bone marrow suppression.
What to do
Avoid concurrent use with systemic mechlorethamine where possible; if combined, monitor blood counts and signs of infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baricitinib and Mechlorethamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Baricitinib with Mechlorethamine?
MediHelp rates the interaction as major. Baricitinib and Mechlorethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baricitinib is immunosuppressive, and systemic mechlorethamine is myelosuppressive, so combined use may raise the risk of serious infection. Topical mechlorethamine has minimal systemic exposure, but the formulation is not specified here.
How serious is the interaction between Baricitinib and Mechlorethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use with systemic mechlorethamine where possible; if combined, monitor blood counts and signs of infection.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
