Drug interactions
Baricitinib + Meclofenamate
Severity: Moderate
Baricitinib and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate may inhibit renal OAT3 and reduce the tubular secretion of baricitinib, raising its exposure. This may increase dose-related adverse effects including infection and cytopenias.
What this interaction means in plain words
Baricitinib and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of baricitinib reduces its elimination.
What to do
Consider an alternative NSAID with weaker OAT3 inhibition, or monitor for infection and blood count changes. Apply the labeled baricitinib dose adjustment for OAT3 inhibitors where it applies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Meclofenamate?
MediHelp rates the interaction as moderate. Baricitinib and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate may inhibit renal OAT3 and reduce the tubular secretion of baricitinib, raising its exposure. This may increase dose-related adverse effects including infection and cytopenias.
How serious is the interaction between Baricitinib and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative NSAID with weaker OAT3 inhibition, or monitor for infection and blood count changes. Apply the labeled baricitinib dose adjustment for OAT3 inhibitors where it applies.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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