Drug interactions
Baricitinib + Penicillin g benzathine
Severity: Minor
Baricitinib and Penicillin g benzathine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins are OAT3 substrates and can compete with baricitinib for renal tubular secretion. Baricitinib exposure may rise modestly, but intramuscular benzathine penicillin gives low, prolonged levels, so the effect is probably small.
What this interaction means in plain words
Baricitinib and Penicillin g benzathine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for OAT3-mediated renal tubular secretion reduces baricitinib clearance.
What to do
No routine dose change is needed. Watch for signs of baricitinib toxicity such as infection or cytopenias if treatment is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Penicillin g benzathine?
MediHelp rates the interaction as minor. Baricitinib and Penicillin g benzathine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins are OAT3 substrates and can compete with baricitinib for renal tubular secretion. Baricitinib exposure may rise modestly, but intramuscular benzathine penicillin gives low, prolonged levels, so the effect is probably small.
How serious is the interaction between Baricitinib and Penicillin g benzathine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for signs of baricitinib toxicity such as infection or cytopenias if treatment is prolonged.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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