Drug interactions
Baricitinib + Rituximab-hyaluronidase
Severity: Major
Baricitinib and Rituximab-hyaluronidase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells and baricitinib suppresses broader immune signaling, so together they raise the risk of serious and opportunistic infection. Combined use is not recommended.
What this interaction means in plain words
Baricitinib and Rituximab-hyaluronidase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from JAK inhibition and CD20-mediated B-cell depletion.
What to do
Avoid the combination where possible. If both are needed, monitor closely for infection and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Rituximab-hyaluronidase?
MediHelp rates the interaction as major. Baricitinib and Rituximab-hyaluronidase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rituximab depletes B cells and baricitinib suppresses broader immune signaling, so together they raise the risk of serious and opportunistic infection. Combined use is not recommended.
How serious is the interaction between Baricitinib and Rituximab-hyaluronidase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor closely for infection and consider antimicrobial prophylaxis.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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