Drug interactions
Baricitinib + Yellow fever vaccine
Severity: Major
Baricitinib and Yellow fever vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is a live attenuated virus that can cause serious vaccine-associated disease in immunosuppressed patients. Baricitinib may also reduce the protective response.
What this interaction means in plain words
Baricitinib and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
JAK inhibition impairs immune control of live attenuated virus replication.
What to do
Avoid yellow fever vaccination during baricitinib therapy. If travel to an endemic area is unavoidable, seek specialist advice, and consider a medical exemption.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Yellow fever vaccine?
MediHelp rates the interaction as major. Baricitinib and Yellow fever vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yellow fever vaccine is a live attenuated virus that can cause serious vaccine-associated disease in immunosuppressed patients. Baricitinib may also reduce the protective response.
How serious is the interaction between Baricitinib and Yellow fever vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yellow fever vaccination during baricitinib therapy. If travel to an endemic area is unavoidable, seek specialist advice, and consider a medical exemption.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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