Drug interactions
Basiliximab + Dengue vaccine
Severity: Major
Basiliximab and Dengue vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from basiliximab may blunt the immune response to dengue vaccination. Because the dengue vaccine is live attenuated, vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
What this interaction means in plain words
Basiliximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Suppressed T-cell activation reduces vaccine response and may permit replication of the live attenuated virus.
What to do
Avoid live dengue vaccine in patients receiving basiliximab and defer vaccination until immunosuppression has resolved. Consider alternative preventive measures such as mosquito avoidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Dengue vaccine?
MediHelp rates the interaction as major. Basiliximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Immunosuppression from basiliximab may blunt the immune response to dengue vaccination. Because the dengue vaccine is live attenuated, vaccination during significant immunosuppression also carries a risk of vaccine-related infection.
How serious is the interaction between Basiliximab and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine in patients receiving basiliximab and defer vaccination until immunosuppression has resolved. Consider alternative preventive measures such as mosquito avoidance.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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