Drug interactions
Basiliximab + Diphtheria and tetanus toxoids / acellular pertussis vaccine
Severity: Moderate
Basiliximab and Diphtheria and tetanus toxoids / acellular pertussis vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Basiliximab may blunt the response to this inactivated combination vaccine. It is not unsafe, but immunity may be less durable.
What this interaction means in plain words
Basiliximab and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-2 receptor blockade reduces T-cell-dependent antibody responses.
What to do
Vaccinate before transplant where possible; otherwise vaccinate as indicated and consider serology for tetanus and diphtheria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as moderate. Basiliximab and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Basiliximab may blunt the response to this inactivated combination vaccine. It is not unsafe, but immunity may be less durable.
How serious is the interaction between Basiliximab and Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before transplant where possible; otherwise vaccinate as indicated and consider serology for tetanus and diphtheria.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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