Drug interactions
Basiliximab + Diphtheria and tetanus toxoids
Severity: Moderate
Basiliximab and Diphtheria and tetanus toxoids: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Basiliximab may reduce the antibody response to toxoid vaccines. These vaccines are non-live so they are not unsafe, but protection may be incomplete.
What this interaction means in plain words
Basiliximab and Diphtheria and tetanus toxoids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-2 receptor blockade reduces T-cell help needed for antibody production.
What to do
Vaccination is not contraindicated; ideally complete it before transplant, otherwise give it and check antibody titers or give boosters if wounds or exposure occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Diphtheria and tetanus toxoids?
MediHelp rates the interaction as moderate. Basiliximab and Diphtheria and tetanus toxoids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Basiliximab may reduce the antibody response to toxoid vaccines. These vaccines are non-live so they are not unsafe, but protection may be incomplete.
How serious is the interaction between Basiliximab and Diphtheria and tetanus toxoids?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination is not contraindicated; ideally complete it before transplant, otherwise give it and check antibody titers or give boosters if wounds or exposure occur.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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