Drug interactions
Basiliximab + Idecabtagene vicleucel
Severity: Major
Basiliximab and Idecabtagene vicleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
What this interaction means in plain words
Basiliximab and Idecabtagene vicleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Idecabtagene vicleucel belongs to Oncology.
Why it happens
Pharmacodynamic antagonism of CAR T-cell proliferation through IL-2 receptor blockade and additive immunosuppression.
What to do
Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Other interactions of Idecabtagene vicleucel
Frequently asked questions
Can I take Basiliximab with Idecabtagene vicleucel?
MediHelp rates the interaction as major. Basiliximab and Idecabtagene vicleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
How serious is the interaction between Basiliximab and Idecabtagene vicleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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