Drug interactions
Basiliximab + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Basiliximab and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Basiliximab blocks IL-2 receptor mediated T-cell activation, which can blunt the antibody response to inactivated vaccines such as adjuvanted influenza vaccine. Patients may therefore be left with inadequate protection despite vaccination.
What this interaction means in plain words
Basiliximab and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: IL-2 receptor blockade impairs T-cell dependent immune response to the vaccine.
What to do
Inactivated influenza vaccine is not contraindicated and should still be given to transplant recipients, ideally before transplant or induction when feasible. Do not rely on a single response; consider serology or additional measures in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Basiliximab and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Basiliximab blocks IL-2 receptor mediated T-cell activation, which can blunt the antibody response to inactivated vaccines such as adjuvanted influenza vaccine. Patients may therefore be left with inadequate protection despite vaccination.
How serious is the interaction between Basiliximab and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated influenza vaccine is not contraindicated and should still be given to transplant recipients, ideally before transplant or induction when feasible. Do not rely on a single response; consider serology or additional measures in high-risk patients.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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