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Drug interactions

Basiliximab + Meningococcal a c y and w-135 polysaccharide vaccine combined

Severity: Moderate

Basiliximab and Meningococcal a c y and w-135 polysaccharide vaccine combined: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Basiliximab may reduce the antibody response to this non-live meningococcal vaccine. It is not unsafe but protection may be incomplete.

What this interaction means in plain words

Basiliximab and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Evidence level: Low

Why it happens

IL-2 receptor blockade reduces T-cell-dependent antibody responses.

What to do

Give the vaccine as indicated, preferably before transplant; consider antibody testing or booster dosing if risk is high.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Basiliximab with Meningococcal a c y and w-135 polysaccharide vaccine combined?

MediHelp rates the interaction as moderate. Basiliximab and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Basiliximab may reduce the antibody response to this non-live meningococcal vaccine. It is not unsafe but protection may be incomplete.

How serious is the interaction between Basiliximab and Meningococcal a c y and w-135 polysaccharide vaccine combined?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as indicated, preferably before transplant; consider antibody testing or booster dosing if risk is high.

What other medicines interact with Basiliximab?

MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.

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