Drug interactions
Basiliximab + Muromonab cd3
Severity: Major
Basiliximab and Muromonab cd3: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are T-cell directed biologic immunosuppressants used in transplantation, and combining them intensifies immunosuppression. This raises the risk of serious infections and lymphoproliferative disorders.
What this interaction means in plain words
Basiliximab and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic immunosuppression through overlapping T-cell inhibition (CD3 depletion plus IL-2 receptor blockade).
What to do
Avoid routine concurrent use of two antilymphocyte induction agents. If both are needed, monitor closely for infection and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Muromonab cd3?
MediHelp rates the interaction as major. Basiliximab and Muromonab cd3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are T-cell directed biologic immunosuppressants used in transplantation, and combining them intensifies immunosuppression. This raises the risk of serious infections and lymphoproliferative disorders.
How serious is the interaction between Basiliximab and Muromonab cd3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two antilymphocyte induction agents. If both are needed, monitor closely for infection and consider antimicrobial prophylaxis.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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