Drug interactions
Basiliximab + Ofatumumab sc
Severity: Moderate
Basiliximab and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair lymphocyte function, so combined or closely sequenced use may increase susceptibility to infections. Ofatumumab depletes B cells for a prolonged period.
What this interaction means in plain words
Basiliximab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from IL-2 receptor blockade and CD20 B-cell depletion.
What to do
Monitor for infection and consider the persistence of immune effects when sequencing the two drugs. Screen for hepatitis B and other relevant infections per ofatumumab labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Basiliximab with Ofatumumab sc?
MediHelp rates the interaction as moderate. Basiliximab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents impair lymphocyte function, so combined or closely sequenced use may increase susceptibility to infections. Ofatumumab depletes B cells for a prolonged period.
How serious is the interaction between Basiliximab and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and consider the persistence of immune effects when sequencing the two drugs. Screen for hepatitis B and other relevant infections per ofatumumab labeling.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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