Drug interactions
Bazedoxifene / conjugated estrogens + Cefadroxil
Severity: Minor
Bazedoxifene / conjugated estrogens and Cefadroxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorised to lower oral estrogen exposure by disrupting gut bacteria involved in enterohepatic recycling. For non-rifamycin antibiotics such as cefadroxil, pharmacokinetic studies have generally not shown a meaningful drop in estrogen levels. Clinical relevance is considered very low.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Cefadroxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Proposed reduction of bacterial deconjugation and enterohepatic recycling of estrogens, which is not well supported for cephalosporins.
What to do
No routine change is needed; the patient may continue therapy. Advise reporting of unexpected bleeding or return of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Cefadroxil?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Cefadroxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorised to lower oral estrogen exposure by disrupting gut bacteria involved in enterohepatic recycling. For non-rifamycin antibiotics such as cefadroxil, pharmacokinetic studies have generally not shown a meaningful drop in estrogen levels. Clinical relevance is considered very low.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Cefadroxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; the patient may continue therapy. Advise reporting of unexpected bleeding or return of menopausal symptoms.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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