Drug interactions
Cefadroxil + Gentamicin
Severity: Moderate
Cefadroxil and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additional kidney injury when given together. Oral cefadroxil has low nephrotoxic potential, so the added risk is generally small.
What this interaction means in plain words
Cefadroxil and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefadroxil belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.
What to do
Monitor serum creatinine and gentamicin levels during therapy. Adjust the gentamicin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Kanamycin Moderate
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Cefadroxil with Gentamicin?
MediHelp rates the interaction as moderate. Cefadroxil and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additional kidney injury when given together. Oral cefadroxil has low nephrotoxic potential, so the added risk is generally small.
How serious is the interaction between Cefadroxil and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during therapy. Adjust the gentamicin dose to renal function.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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