Drug interactions
Bazedoxifene / conjugated estrogens + Cefotaxime
Severity: Minor
Bazedoxifene / conjugated estrogens and Cefotaxime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce oral estrogen levels by disrupting gut flora involved in enterohepatic recirculation. Evidence for a clinically meaningful effect with cephalosporins is weak, and this product is used for menopausal symptoms rather than contraception.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Cefotaxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recycling of estrogen due to altered gut flora.
What to do
No routine action is needed. Reassess if menopausal symptoms or bleeding patterns change during antibiotic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene / conjugated estrogens and Cefotaxime, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cefotaxime
- Cefotaxime + Typhoid vaccine live Major
- Amikacin + Cefotaxime Moderate
- Cefotaxime + Cholera vaccine Moderate
- Cefotaxime + Dexamethasone-tobramycin Moderate
- Cefotaxime + Gentamicin Moderate
- Cefotaxime + Kanamycin Moderate
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Cefotaxime?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Cefotaxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce oral estrogen levels by disrupting gut flora involved in enterohepatic recirculation. Evidence for a clinically meaningful effect with cephalosporins is weak, and this product is used for menopausal symptoms rather than contraception.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Cefotaxime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Reassess if menopausal symptoms or bleeding patterns change during antibiotic therapy.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
