Drug interactions
Bazedoxifene / conjugated estrogens + Cyclosporin
Severity: Moderate
Bazedoxifene / conjugated estrogens and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase exposure to the estrogen and bazedoxifene components by reducing their intestinal and hepatic metabolism and efflux. This could increase estrogenic adverse effects such as breast tenderness, fluid retention and thromboembolic risk. The clinical effect is generally modest.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing first-pass metabolism and efflux of the components.
What to do
Monitor for estrogen-related adverse effects and adjust the estrogen dose if they occur. Also monitor cyclosporine levels, since estrogens can alter them.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Cyclosporin?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase exposure to the estrogen and bazedoxifene components by reducing their intestinal and hepatic metabolism and efflux. This could increase estrogenic adverse effects such as breast tenderness, fluid retention and thromboembolic risk. The clinical effect is generally modest.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects and adjust the estrogen dose if they occur. Also monitor cyclosporine levels, since estrogens can alter them.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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