Drug interactions
Bazedoxifene / conjugated estrogens + Efavirenz
Severity: Moderate
Bazedoxifene / conjugated estrogens and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower exposure to the estrogen and bazedoxifene components, potentially reducing efficacy. The endometrial protection provided by bazedoxifene could be diminished.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by efavirenz and possible UGT induction increase metabolism of the components.
What to do
Monitor for recurrence of menopausal symptoms and abnormal bleeding, and consider alternative therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene / conjugated estrogens and Efavirenz, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Efavirenz?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower exposure to the estrogen and bazedoxifene components, potentially reducing efficacy. The endometrial protection provided by bazedoxifene could be diminished.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of menopausal symptoms and abnormal bleeding, and consider alternative therapy if response is lost.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
