Drug interactions
Bazedoxifene / conjugated estrogens + Enoxaparin
Severity: Major
Bazedoxifene / conjugated estrogens and Enoxaparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens and bazedoxifene increase thromboembolic risk, which works against anticoagulation. Patients needing enoxaparin for active thrombosis should not take them.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Prothrombotic effects of estrogens and SERM oppose anticoagulation.
What to do
Stop the estrogen product during treatment of venous thromboembolism and reassess its need.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Enoxaparin?
MediHelp rates the interaction as major. Bazedoxifene / conjugated estrogens and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogens and bazedoxifene increase thromboembolic risk, which works against anticoagulation. Patients needing enoxaparin for active thrombosis should not take them.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Enoxaparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the estrogen product during treatment of venous thromboembolism and reassess its need.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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