Drug interactions
Bazedoxifene / conjugated estrogens + Erythromycin
Severity: Minor
Bazedoxifene / conjugated estrogens and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly increase exposure to the estrogen component through CYP3A4 inhibition. The clinical significance is generally limited, though it could increase estrogen-related adverse effects.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by erythromycin reducing estrogen metabolism.
What to do
No routine change is needed; monitor for estrogenic adverse effects such as breast tenderness or bleeding changes during a short antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Erythromycin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may modestly increase exposure to the estrogen component through CYP3A4 inhibition. The clinical significance is generally limited, though it could increase estrogen-related adverse effects.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for estrogenic adverse effects such as breast tenderness or bleeding changes during a short antibiotic course.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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