Drug interactions
Bazedoxifene / conjugated estrogens + Griseofulvin
Severity: Moderate
Bazedoxifene / conjugated estrogens and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may induce estrogen metabolism and lower conjugated estrogen exposure, which could reduce relief of menopausal symptoms. Reduced endometrial protection may also be a concern in theory.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by griseofulvin increases estrogen metabolism, with possible effect on bazedoxifene glucuronidation.
What to do
Monitor for recurrent vasomotor symptoms or abnormal bleeding and adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Griseofulvin?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may induce estrogen metabolism and lower conjugated estrogen exposure, which could reduce relief of menopausal symptoms. Reduced endometrial protection may also be a concern in theory.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent vasomotor symptoms or abnormal bleeding and adjust therapy if efficacy is lost.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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