Drug interactions
Bazedoxifene / conjugated estrogens + Imipramine
Severity: Minor
Bazedoxifene / conjugated estrogens and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens may alter tricyclic antidepressant exposure, and some reports describe higher imipramine concentrations with more anticholinergic, sedative or cardiovascular adverse effects. Others describe reduced antidepressant response. The effect is inconsistent and usually modest.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens may modestly inhibit hepatic oxidative metabolism of tricyclics, but the mechanism is not firmly established.
What to do
No routine dose change is needed; watch for anticholinergic or sedative effects or loss of antidepressant response when estrogen therapy is started or stopped, and adjust imipramine to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Imipramine?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral estrogens may alter tricyclic antidepressant exposure, and some reports describe higher imipramine concentrations with more anticholinergic, sedative or cardiovascular adverse effects. Others describe reduced antidepressant response. The effect is inconsistent and usually modest.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for anticholinergic or sedative effects or loss of antidepressant response when estrogen therapy is started or stopped, and adjust imipramine to clinical response.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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