Drug interactions
Bazedoxifene / conjugated estrogens + Ketoconazole
Severity: Moderate
Bazedoxifene / conjugated estrogens and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise exposure to the estrogen and bazedoxifene components. This could increase estrogenic adverse effects, including thromboembolism and endometrial effects.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ketoconazole decreases metabolism of the estrogens.
What to do
Monitor for estrogen excess such as breast tenderness or bleeding. Consider an alternative antifungal if therapy is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Ketoconazole?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise exposure to the estrogen and bazedoxifene components. This could increase estrogenic adverse effects, including thromboembolism and endometrial effects.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess such as breast tenderness or bleeding. Consider an alternative antifungal if therapy is prolonged.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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