Drug interactions
Bazedoxifene / conjugated estrogens + Nilotinib
Severity: Minor
Bazedoxifene / conjugated estrogens and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and may modestly raise concentrations of the estrogen and bazedoxifene components. This could increase estrogen-related adverse effects such as breast tenderness and thromboembolic risk.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux by nilotinib.
What to do
No routine dose change is needed. Watch for estrogenic adverse effects and reassess therapy if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Nilotinib?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP3A4 and P-glycoprotein and may modestly raise concentrations of the estrogen and bazedoxifene components. This could increase estrogen-related adverse effects such as breast tenderness and thromboembolic risk.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for estrogenic adverse effects and reassess therapy if they develop.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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