Drug interactions
Bazedoxifene / conjugated estrogens + Nortriptyline
Severity: Minor
Bazedoxifene / conjugated estrogens and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant exposure, leading to more anticholinergic and cardiovascular adverse effects, and may in some patients blunt antidepressant response. The effect is variable and usually modest.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogens may inhibit hepatic oxidative metabolism of tricyclics; the mechanism is not firmly established.
What to do
Monitor antidepressant response and tricyclic adverse effects when estrogen therapy is started or stopped, and adjust the nortriptyline dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Nortriptyline?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant exposure, leading to more anticholinergic and cardiovascular adverse effects, and may in some patients blunt antidepressant response. The effect is variable and usually modest.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tricyclic adverse effects when estrogen therapy is started or stopped, and adjust the nortriptyline dose if needed.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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