Drug interactions
Bazedoxifene / conjugated estrogens + Oxcarbazepine
Severity: Moderate
Bazedoxifene / conjugated estrogens and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can lower estrogen exposure through enzyme induction. This may cause loss of symptom control and reduced endometrial protection from the combination.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction increases estrogen metabolism; bazedoxifene is mainly cleared by glucuronidation, which can also be induced.
What to do
Monitor for recurrence of vasomotor symptoms and for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Oxcarbazepine?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can lower estrogen exposure through enzyme induction. This may cause loss of symptom control and reduced endometrial protection from the combination.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of vasomotor symptoms and for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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