Drug interactions
Bazedoxifene / conjugated estrogens + Tolvaptan
Severity: Minor
Bazedoxifene / conjugated estrogens and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits the P-glycoprotein efflux transporter, which could modestly raise exposure to P-gp substrates. The clinical importance for bazedoxifene and conjugated estrogens is uncertain and probably small.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Tolvaptan inhibition of P-glycoprotein may increase absorption or reduce efflux of substrates.
What to do
No routine adjustment is needed; monitor for increased estrogenic or bazedoxifene adverse effects if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Tolvaptan?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits the P-glycoprotein efflux transporter, which could modestly raise exposure to P-gp substrates. The clinical importance for bazedoxifene and conjugated estrogens is uncertain and probably small.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for increased estrogenic or bazedoxifene adverse effects if the combination is used.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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