Drug interactions
Bcg vaccine live + Cabazitaxel
Severity: Major
Bcg vaccine live and Cabazitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabazitaxel is immunosuppressive, and a live attenuated BCG vaccine can cause disseminated BCG infection in immunocompromised patients. The immune response to the vaccine may also be inadequate.
What this interaction means in plain words
Bcg vaccine live and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs control of live attenuated bacteria and reduces vaccine response.
What to do
Avoid live BCG vaccination during cabazitaxel therapy and for at least 3 months afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Bcg vaccine live with Cabazitaxel?
MediHelp rates the interaction as major. Bcg vaccine live and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cabazitaxel is immunosuppressive, and a live attenuated BCG vaccine can cause disseminated BCG infection in immunocompromised patients. The immune response to the vaccine may also be inadequate.
How serious is the interaction between Bcg vaccine live and Cabazitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live BCG vaccination during cabazitaxel therapy and for at least 3 months afterward.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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