Drug interactions
Atazanavir + Cabazitaxel
Severity: Major
Atazanavir and Cabazitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can markedly raise cabazitaxel exposure. This increases the risk of severe neutropenia and other toxicities of cabazitaxel.
What this interaction means in plain words
Atazanavir and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Cabazitaxel belongs to Oncology.
Why it happens
Atazanavir inhibits CYP3A4-mediated metabolism of cabazitaxel.
What to do
Avoid concomitant use of strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider reducing the cabazitaxel dose and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Cabazitaxel?
MediHelp rates the interaction as major. Atazanavir and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can markedly raise cabazitaxel exposure. This increases the risk of severe neutropenia and other toxicities of cabazitaxel.
How serious is the interaction between Atazanavir and Cabazitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider reducing the cabazitaxel dose and monitor blood counts closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Cabazitaxel page.
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