Drug interactions
Bcg vaccine live + Ceftriaxone
Severity: Minor
Bcg vaccine live and Ceftriaxone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG is a viable bacterial vaccine, and an antibiotic active against it could reduce its replication and weaken the immune response. However, BCG is intrinsically resistant to most cephalosporins, so the interaction is largely theoretical.
What this interaction means in plain words
Bcg vaccine live and Ceftriaxone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical antibacterial activity against the live vaccine organism; BCG is generally not susceptible to ceftriaxone.
What to do
No routine delay is needed for BCG with ceftriaxone; vaccinate according to the schedule, and consider postponing only if the patient is acutely and severely ill.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Frequently asked questions
Can I take Bcg vaccine live with Ceftriaxone?
MediHelp rates the interaction as minor. Bcg vaccine live and Ceftriaxone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Live BCG is a viable bacterial vaccine, and an antibiotic active against it could reduce its replication and weaken the immune response. However, BCG is intrinsically resistant to most cephalosporins, so the interaction is largely theoretical.
How serious is the interaction between Bcg vaccine live and Ceftriaxone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine delay is needed for BCG with ceftriaxone; vaccinate according to the schedule, and consider postponing only if the patient is acutely and severely ill.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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