Drug interactions
Bcg vaccine live + Ofloxacin
Severity: Moderate
Bcg vaccine live and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin has some activity against mycobacteria, which could in theory reduce the viability of BCG. Clinical evidence of reduced vaccine response is lacking.
What this interaction means in plain words
Bcg vaccine live and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible antibacterial action against the live attenuated BCG strain.
What to do
Defer BCG vaccination until the antibiotic course is complete where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Bcg vaccine live with Ofloxacin?
MediHelp rates the interaction as moderate. Bcg vaccine live and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin has some activity against mycobacteria, which could in theory reduce the viability of BCG. Clinical evidence of reduced vaccine response is lacking.
How serious is the interaction between Bcg vaccine live and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer BCG vaccination until the antibiotic course is complete where feasible.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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